Last update: Aug. 30, 2018
Very unsafe. Contraindicated.
Use of an alternative or cessation of breastfeeding.
We do not have alternatives for Danazol.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
Danazol in other languages or writings:
Danazol belongs to this group or family:
Main tradenames from several countries containing Danazol in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 100 | % |
Molecular weight | 338 | daltons |
pKa | 13,1 | - |
Tmax | 2 | hours |
T1/2 | 4,5 - 29 | hours |
Write to us at elactancia.org@gmail.com
e-lactancia is a resource recommended by IHAN from Spain
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A synthetic steroid with antigonadotropic and antiestrogenic activity due to the suppression of the pituitary gland’s gonadotropic hormone and with androgenic effects (Sanofi 2017, AEMPS 2017).
Used to treat endometriosis, fibrocystic breast disease, hereditary angioedema, mastalgia, premenstrual syndrome and menorrhagia.
Administration orally twice a day.
Since the last update we have not found published data on its excretion in breastmilk or its effect on breastfed infants (Briggs 2017).
In the absence of data regarding protein binding and the volume of distribution, the known pharmacokinetic data (low molecular weight, high pKa and prolonged half-life) make it likely that it would transfer to milk in amounts which could be significant.
Due to its possible androgenic effect on the infant and inhibition of prolactin, it should be avoided during breastfeeding (Hale 2019 p193, Sanofi 2017, AEMPS 2017).