Last update June 18, 2022


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Melitracen is a tricyclic antidepressant given with flupentixol in the management of depression with anxiety. Oral administration in two or three daily doses.

Since the last update we have not found any published data on its excretion in breast milk.

Its pharmacokinetic characteristics (high plasma protein binding and large volume of distribution) make it very unlikely its excretion into breast milk in significant amounts.

Amitriptyline, another similar tricyclic antidepressant, is excreted in breast milk in clinically insignificant amounts.

The manufacturer consider the use of this medication to be safe during breastfeeding. (AEMPS 2021, Lundbeck 2020)



See below the information of these related products:

  • Amitriptyline (Safe substance and/or breastfeeding is the best option.)
  • Flupentixol (Safe substance and/or breastfeeding is the best option.)
  • Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

塩酸メリトラセン is Melitracen Hydrochloride in Japanese.

Is written in other languages:

塩酸メリトラセン is also known as


塩酸メリトラセン belongs to these groups or families:


Main tradenames from several countries containing 塩酸メリトラセン in its composition:

  • Deanxit™. Contains other elements than 塩酸メリトラセン in its composition


Variable Value Unit
Molecular weight 328 daltons
Protein Binding 89 %
VD 31.4 l/Kg
Tmax 5 hours
62 hours


  1. AEMPS-Lundbeck. Flupentixol-Melitraceno (Deanxit) Ficha técnica. 2021 Full text (in our servers)
  2. Lundbeck Hellas A.E. Flupentixol-Melitracen (Deanxit). Drug Summary 2020 Full text (in our servers)
  3. Wu L, Xu C, Wu G, Zhou H, Lv D, Zhai Y, Huang Y, Tang W, Li F, Shentu J. Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions. Drug Des Devel Ther. 2019 Sep 19;13:3331-3342. Abstract

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at

e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM