Last update June 18, 2022
Melitracen is a tricyclic antidepressant given with flupentixol in the management of depression with anxiety. Oral administration in two or three daily doses.
Since the last update we have not found any published data on its excretion in breast milk.
Its pharmacokinetic characteristics (high plasma protein binding and large volume of distribution) make it very unlikely its excretion into breast milk in significant amounts.
Amitriptyline, another similar tricyclic antidepressant, is excreted in breast milk in clinically insignificant amounts.
The manufacturer consider the use of this medication to be safe during breastfeeding. (AEMPS 2021, Lundbeck 2020)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America
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