Last update June 25, 2022

Flupentixol

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is a typical, first generation antipsychotic, with general properties similar to those of chlorpromazine, that is used for the treatment of chronic schizophrenia and other psychoses. Oral administration in two daily doses.

It is excreted in breast milk in clinically insignificant amounts (AEMPS 2021, Lundbeck 2020, Matheson 1988, Kirk 1980) and no problems have been observed in infants whose mothers have taken it (Matheson 1988. Plasma levels in these infants were very low. (Matheson 1988)

May increase prolactin levels and cause galactorrhea. (Bostwick 2009, Kropp 2004)

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.

The manufacturer consider the use of this medication to be safe during breastfeeding. (AEMPS 2021, Lundbeck 2020)

 

Expert authors consider the use of this medication possible during breastfeeding.. (Hale, Uguz 2021, Schaefer 2015)


See below the information of this related product:

Alternatives

  • Olanzapine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Risperidone ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Zuclopenthixol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Flupentixol is also known as


Flupentixol in other languages or writings:

Groups

Flupentixol belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Flupentixol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 40 %
Molecular weight 435 daltons
Protein Binding 99 %
VD 14.1 l/Kg
pKa 15.59 -
Tmax 6 (3 - 8) hours
35 - 61 hours
M/P ratio 1 -
Theoretical Dose 0.0003 - 0.0004 mg/Kg/d
Relative Dose 0.6 - 0.7 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. AEMPS-Lundbeck. Flupentixol-Melitraceno (Deanxit) Ficha técnica. 2021 Full text (in our servers)
  3. Uguz F. A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation. Am J Ther. 2021 Jan-Feb 01;28(1):e118-e126. Abstract
  4. Lundbeck Hellas A.E. Flupentixol-Melitracen (Deanxit). Drug Summary 2020 Full text (in our servers)
  5. Wu L, Xu C, Wu G, Zhou H, Lv D, Zhai Y, Huang Y, Tang W, Li F, Shentu J. Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions. Drug Des Devel Ther. 2019 Sep 19;13:3331-3342. Abstract
  6. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  7. Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. Abstract
  8. Bostwick JR, Guthrie SK, Ellingrod VL. Antipsychotic-induced hyperprolactinemia. Pharmacotherapy. 2009 Jan;29(1):64-73. Abstract
  9. Kropp S, Ziegenbein M, Grohmann R, Engel RR, Degner D. Galactorrhea due to psychotropic drugs. Pharmacopsychiatry. 2004 Mar;37 Suppl 1:S84-8. Abstract
  10. Matheson I, Skjaeraasen J. Milk concentrations of flupenthixol, nortriptyline and zuclopenthixol and between-breast differences in two patients. Eur J Clin Pharmacol. 1988 Abstract
  11. Kirk L, Jørgensen A. Concentrations of Cis(Z)-flupentixol in maternal serum, amniotic fluid, umbilical cord serum, and milk. Psychopharmacology (Berl). 1980;72(1):107-8. Abstract

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