Chlorpromazine

Typical, first generation antipsychotic. A central nervous system tranquilizing agent with antipsychotic, anxiolytic and antiemetic properties. Oral or intramuscular administration 1 to 3 times a day.

It is excreted in breastmilk in very small to undetectable amounts ^{(Zuppa 2010, Yoshida 1998, Ohkubo 1993, Wiles 1978, Uhlir 1973)}, even after maternal doses of 1200 mg. ^{(Blacker 1962)}

The urine levels of two infants whose mothers took chlorpromazine were very low, around 1 microgram/L. ^{(Yoshida 1998)}

In infants whose mothers were taking chlorpromazine, reports have ranged from no side effects ^{(Wiles 1978, Ayd 1964, Kris 1957)} with normal growth and neurological development ^{(Lacey 1971, Kris 1962)} to numbness and sedation ^{(Lee 1993, Wiles 1978, Lacey 1971)} with decreased developmental score at 12 and 18 months when taking other psychotropic medications at the same time. ^{(Yoshida 1998)}

Because it is a dopamine inhibitor, it produces an increase in prolactin levels and can increase milk production, having been used as a galactogogue. ^{(Lawrence 2016 p670, Mannion 2012, Muresan 2011, Zuppa 2010, Gabay 2002)}

The use of chlorpromazine during lactation is possible ^{(Hale, Uguz 2021)}. Monitoring of drowsiness and development in infants is required ^{(Klinger 2013, WHO 2002)} and prescribing it at the lowest effective dose and, if possible, as monotherapy ^{(Parikh 2014, Tényi 2000)}. Doses of 100 mg per day do not cause problems for the infant. ^{(Lawrence 2016 p394)}

See below the information of this related product:

• Maternal Psychotic Disorder. Maternal psychosis, schizophrenia, bipolar disorder (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)