Last update Nov. 16, 2014

Perphenazine

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

One reportedly case of use by a mother for 3,5 months (8 - 12 mg x 2 / daily) without harm effects on the child. Check-up for lethargy or dyskinetic symptoms.

Alternatives

We do not have alternatives for Perphenazine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Perphenazine is also known as


Group

Perphenazine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Perphenazine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 403 daltons
Protein Binding 99 %
Tmax 4 hours
T1/2 12 hours
M/P ratio 1 -
Theoretical Dose 0,0005 mg/Kg/d
Relative Dose 0,25 %
Ped.Relat.Dose 0,05 %

References

  1. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  2. Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. Abstract
  3. Rubin ET, Lee A, Ito S. When breastfeeding mothers need CNS-acting drugs. Can J Clin Pharmacol. 2004 Fall;11(2):e257-66. Epub 2004 Dec 8. Abstract

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