Last update June 18, 2022
Very Low Risk
Tricyclic antidepressant, active metabolite of amitriptyline. Oral administration 3 to 4 times a day
Excreted into breast milk in a clinically non-significant amount (Wisner 1997, Breyer 1995, Matheson 1988, Brixen1982) with no problems observed in breastfed infants from treated mothers. (Wisner 2002, 1997 y 1991, Misri 1991, Brixen1982)
Levels found in the plasma of those infants were very low or undetectable. (Wisner 2006, 1996 y 1991, Birnbaum 1999, Altshuler 1995, Brixen 1982, Erickson 1979)
Expert authors consider the use of this medication to be safe or very probably safe during breastfeeding (Hale, Uguz 2021, Sriraman 2015, Hübner 2012). Along with sertraline and paroxetine, it is considered one of the safest antidepressants during lactation. (Gentile 2014, Nielsen 2012, Hübner 2012, Pringsheim 2012, Davanzo 2011, Lanza 2009, ABM 2008, Weissman 2004, Gjerdingen 2003)
Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. (Grzeskowiak 2018, Leggett 2017, Gorman 2012)
We do not have alternatives for Nortriptyline Hydrochloride since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM