Last update June 29, 2022
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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The sodium salt of 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide is Tianeptine Sodium in Chemical name.
Is written in other languages:The sodium salt of 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide belongs to these groups or families:
Main tradenames from several countries containing The sodium salt of 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 99 | % |
Molecular weight | 459 | daltons |
Protein Binding | 95 | % |
VD | 0.8 | l/Kg |
pKa | 4.22 | - |
Tmax | 1 - 2 | hours |
T½ | 2.5 - 3 (Metab: 7 - 8) | hours |
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Drug with similar efficacy as other antidepressants with tricyclic and selective inhibitors of serotonin reuptake characteristics. Oral administration three times a day.
At latest update no published data on excretion into breast milk were found.
Its pharmacokinetic data (very high percentage of protein binding, moderately high molecular weight and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.
Neonatal Abstinence Syndrome has been published after abusing doses (more than 100 times higher than usual) of Tianeptine during pregnancy. (Bence 2016)
t may, like other antidepressants, increase Prolactin levels in the plasma. (Filho 2007)
Risk of abuse and dependence with addiction (Lauhan 2018, Vadachkoria 2009, Kisa 2007, Prescrire 2007), which is a reason not to be authorized in many countries.
Until more published data regarding breastfeeding is available, the use of a known and safer alternative drug should be preferred, especially during the neonatal period and/or in case of premature infant.
See below the information of this related product: