Last update June 29, 2022


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Drug with similar efficacy as other antidepressants with tricyclic and selective inhibitors of serotonin reuptake characteristics. Oral administration three times a day.

At latest update no published data on excretion into breast milk were found.

Its pharmacokinetic data (very high percentage of protein binding, moderately high molecular weight and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Neonatal Abstinence Syndrome has been published after abusing doses (more than 100 times higher than usual) of Tianeptine during pregnancy. (Bence 2016)

t may, like other antidepressants, increase Prolactin levels in the plasma. (Filho 2007)

Risk of abuse and dependence with addiction (Lauhan 2018, Vadachkoria 2009, Kisa 2007, Prescrire 2007), which is a reason not to be authorized in many countries.

Until more published data regarding breastfeeding is available, the use of a known and safer alternative drug should be preferred, especially during the neonatal period and/or in case of premature infant.

See below the information of this related product:

  • Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

チアネプチンナトリウム塩 is Tianeptine Sodium in Japanese.

Is written in other languages:


チアネプチンナトリウム塩 belongs to these groups or families:


Main tradenames from several countries containing チアネプチンナトリウム塩 in its composition:


Variable Value Unit
Oral Bioavail. 99 %
Molecular weight 459 daltons
Protein Binding 95 %
VD 0.8 l/Kg
pKa 4.22 -
Tmax 1 - 2 hours
2.5 - 3 (Metab: 7 - 8) hours


  1. AEMPS. Tianeptina. Ficha técnica. 2019 Full text (in our servers)
  2. Lauhan R, Hsu A, Alam A, Beizai K. Tianeptine Abuse and Dependence: Case Report and Literature Review. Psychosomatics. 2018 Nov;59(6):547-553. Abstract
  3. Bence C, Bonord A, Rebillard C, Vaast P, Alexandre C, Jardri R, Rolland B. Neonatal Abstinence Syndrome Following Tianeptine Dependence During Pregnancy. Pediatrics. 2016 Abstract
  4. Vadachkoria D, Gabunia L, Gambashidze K, Pkhaladze N, Kuridze N. Addictive potential of Tianeptine - the threatening reality. Georgian Med News. 2009 Abstract
  5. Kisa C, Bulbul DO, Aydemir C, Goka E. Is it possible to be dependent to Tianeptine, an antidepressant? A case report. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Abstract
  6. Filho RB, Domingues L, Naves L, Ferraz E, Alves A, Casulari LA. Polycystic ovary syndrome and hyperprolactinemia are distinct entities. Gynecol Endocrinol. 2007 Abstract
  7. [No authors listed] Tianeptine abuse: yet again. Prescrire Int. 2007 Abstract
  8. Dresse A, Rosen JM, Brems H, Masset H, Defrance R, Salvadori C. Influence of food on tianeptine and its main metabolite kinetics. J Clin Pharmacol. 1988 Abstract
  9. Royer RJ, Albin H, Barrucand D, Salvadori-Failler C, Kamoun A. Pharmacokinetic and metabolic parameters of tianeptine in healthy volunteers and in populations with risk factors. Clin Neuropharmacol. 1988 Abstract

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