Натрий Тианептин

Drug with similar efficacy as other antidepressants with tricyclic and selective inhibitors of serotonin reuptake characteristics. Oral administration three times a day.

At latest update no published data on excretion into breast milk were found.

Its pharmacokinetic data (very high percentage of protein binding, moderately high molecular weight and wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Neonatal Abstinence Syndrome has been published after abusing doses (more than 100 times higher than usual) of Tianeptine during pregnancy. ^{(Bence 2016)}

t may, like other antidepressants, increase Prolactin levels in the plasma. ^{(Filho 2007)}

Risk of abuse and dependence with addiction ^{(Lauhan 2018, Vadachkoria 2009, Kisa 2007, Prescrire 2007)}, which is a reason not to be authorized in many countries.

Until more published data regarding breastfeeding is available, the use of a known and safer alternative drug should be preferred, especially during the neonatal period and/or in case of premature infant.

See below the information of this related product:

• Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)