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An alkaloid found in the roots of Rauwolfia serpentina or Rauwolfia vomitoria, a shrub which is native to India, withdrawal or restricted from the market in Spain (MSC 2004). Reserpine was the first antihypertensive ever used, nowadays superseded by new products with fewer side effects. It has centrally-acting antidrenergic effects. It can cause sedation and hypotonia. It has been used to treat hypertension and in psychosis. Oral administration once a day.
Since the last update we have not found any published data on its excretion in breast milk.
There are unconfirmed out-of-date reports that state it is excreted in breastmilk (Nice 2004, White 1984). Its pharmacokinetic data - not very high molecular weight, low protein binding and very long half-life (Infomed 2018) - makes transfer to milk possible in amounts that could be significant.
It can produce hyperprolactinemia (Molitch 1992, Camanni 1981, Lee 1976).
This product is very little used at present, with a lack of bibliographic data on its pharmacokinetics.
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable (Malachias 2016, WHO 2002), especially during the neonatal period and in cases of prematurity.