Last update March 7, 2021


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Enalapril is an angiotensin converting enzyme (ACE) inhibitor used in the treatment of high blood pressure and heart failure.
Oral administration every 12-24 hours.

It is excreted in breastmilk in clinically insignificant amounts (Anderson 2018, Serrano 2015, Rush 1991, Redman 1990, Kirsten 1998, Huttunen 1989) and no problems have been observed in infants whose mothers were taking it (Anderson 2018, Rush 1991, Huttunen 1989 ), nor problems in the establishment of breastfeeding (Bach 1995).

It use is authorized in small infants and, off-label, in neonates. (FDA 2018, Kirsten 1998)

Due to its possible renal toxicity in preterm infants, it is preferable to avoid its use during the neonatal period in the case of prematurity. (Serrano 2015).

Expert authors and medical associations such as the American Academy of Pediatrics consider it to be a drug which is usually compatible with breastfeeding (Ghelfi 2021, Serrano 2015, Rowe 2013, Dennis 2012, Ghanem 2008, AAP 2001, Kirsten 1998).

The protective role of breastfeeding against maternal hypertension has been proven (Park 2018).


We do not have alternatives for Enalapril since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Enalapril is also known as

Enalapril in other languages or writings:


Enalapril belongs to this group or family:


Main tradenames from several countries containing Enalapril in its composition:


Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 492 daltons
Protein Binding 60 %
VD 1,7 l/Kg
pKa 3,67 -
Tmax 1,5 hours
T1/2 11 hours
M/P ratio 0,8 -
Theoretical Dose 0,0009 mg/Kg/d
Relative Dose 0,56 %
Ped.Relat.Dose 0,18 - 0,9 %

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