Last update June 25, 2022

氯噻平

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Atypical or second-generation antipsychotic indicated for the treatment of schizophrenia and other psychotic disorders. Oral administration in two to three daily doses.

Since the last update, we have not found any published data on its excretion in breastmilk.

The little pharmacokinetic data that is known makes it difficult to predict its excretion in breastmilk.

It has very few and/or very old bibliographic references and is sold in very few countries for reasons of efficacy and efficiency compared to other antipsychotics. (Carpenter 2004)

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in cases of prematurity.


See below the information of this related product:

Alternatives

  • Chlorpromazine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Haloperidol (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Olanzapine (Safe product and/or breastfeeding is the best option.)
  • Perphenazine (Safe product and/or breastfeeding is the best option.)
  • Risperidone (Safe product and/or breastfeeding is the best option.)
  • Trifluoperazine Hydrochloride (Safe product and/or breastfeeding is the best option.)
  • Zuclopenthixol (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

氯噻平 is Clotiapine; Clothiapine in Chinese.

Is written in other languages:

Tradenames

Main tradenames from several countries containing 氯噻平 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 ± 12 %
Molecular weight 344 daltons
pKa 7.23 -
Tmax 1.09 ± 0.27 hours
7.05 ± 3.79 hours

References

  1. AEMPS - Juvisé. Clotiapina (Etumina). Ficha técnica. 2018 Full text (in our servers)
  2. Carpenter S, Berk M, Rathbone J. Clotiapine for acute psychotic illnesses. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD002304. Review. Abstract

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