Last update Feb. 9, 2023
Limited compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Etretinate in other languages or writings:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 100 | % |
Molecular weight | 354 | daltons |
Protein Binding | 99 | % |
Tmax | 6 | hours |
T½ | 2880 | hours |
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e-lactancia is a resource recommended by La Liga de la Leche, España of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Synthetic retinoid derivated from vitamin A. It is a derivative of tretinoin and is metabolized to acitretin. It is used in the treatment of severe forms of psoriasis, ichthyosis, Darier's disease and lichen planus. Oral administration.
At the date of the last update we did not find any published data on its excretion in breast milk.
Despite a low amount of acitretin secreted through the breast milk, less than 2% of the maternal equivalent dose (Rollman 1990), some expert authors(Hale 2019, Butler 2014, Mervic 2014, Schaefer2007, Rollman 1990) think that product's toxicity justifies to avoid it during breastfeeding.
Others consider acitretin compatible with breastfeeding (Briggs 2017). American Academy of Pediatrics: Maternal medication usually compatible with breastfeeding. (AAP 2001)
Acitretin can cause gynecomastia. (Atzenhoffer 2018)
Etretinate has been replaced by acitretin in clinical use.
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.