Last update Jan. 25, 2025

Clobetasol Propionate

Compatible

Safe product and/or breastfeeding is the best option.

Very high potency topical corticosteroid.

At the date of last update, we found no published data on its excretion in breast milk.

No problems were observed in an infant whose mother was treated with topical clobetasol for pemphigoid gestationis (herpes gestationis).(Westermann 2012)

The small dose and poor plasma absorption of most topical dermatologic preparations make passage of significant amount into breast milk unlikely.

If required to treat eczema or nipple dermatosis it is advisable to choose corticosteroids of lower potency (Barrett 2013, Heller 2012), apply them just after the feeding so that they have been reabsorbed before the next feeding, if necessary remove remains with a gauze and do not use for more than one week in a row.

Mineralcorticoid intoxication has occurred in an infant due to continuous application of a corticoid on the nipple. (De Stefano 1983)

The application of creams, gels and other locally applied products containing kerosene (mineral oil) on the nipple should be avoided so that the infant does not absorb it. (Concin 2008, Noti 2003)

Alternatives

We do not have alternatives for Clobetasol Propionate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Clobetasol Propionate in other languages or writings:

Group

Clobetasol Propionate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Clobetasol Propionate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 467 daltons

References

  1. Barrett ME, Heller MM, Fullerton Stone H, Murase JE. Dermatoses of the breast in lactation. Dermatol Ther. 2013 Abstract
  2. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Feb;39(2):168-71. Abstract
  3. Heller MM, Fullerton-Stone H, Murase JE. Caring for new mothers: diagnosis, management and treatment of nipple dermatitis in breastfeeding mothers. Int J Dermatol. 2012 Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  6. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983 Abstract

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