Last update July 31, 2018
Compatible
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Pimecrolimus in other languages or writings:
Main tradenames from several countries containing Pimecrolimus in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | Dermat: baja - poor | % |
Molecular weight | 811 | daltons |
Protein Binding | 74 - 99.6 | % |
Tmax | 2 | hours |
T½ | 100 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
An immunomodulator and calcineurin inhibitor related to tacrolimus. Used in the treatment of atopic dermatitis.
Used topically as a cream and orally in research studies.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data (moderately high molecular weight, high percentage of protein binding and very little systemic absorption with topical use (less than 2 micrograms/L in plasma) (AEMPS 2013, FDA 2001) make it unlikely that will be transferred to milk in significant quantities (AEMPS 2013).
Do not apply on the breast in order to prevent the infant from swallowing it (AEMPS 2013, Barret 2013, Butler 2014); if necessary, apply after a feed and clean well with water before the next feed.
It is advisable to avoid the application of creams, gels and other local application products containing paraffin (mineral oil) on the nipple so that the infant does not absorb them (Noti 2003, Concin 2008).