Last update Nov. 13, 2024

Anthralin, Dithranol

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Anthralin is a natural derivative of anthraquinone (tar), an antipsoriatic and anti-inflammatory agent. It is one of the first-line drugs in the treatment of psoriasis. Topical cutaneous administration.

At the date of the last update we found no published data on its excretion in breast milk.

Absorbed drug is excreted almost instantaneously through the kidneys, so plasma levels are very low or undetectable. (Hale, Goodfield 1994)

Given the possible mutagenic properties, infant skin should not come into contact with treated areas of maternal skin.  It should not be applied to the breast so that the infant cannot ingest the product. (Gottlieb 2019)

Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Anthralin, Dithranol is also known as


Anthralin, Dithranol in other languages or writings:

Group

Anthralin, Dithranol belongs to this group or family:

Tradenames

Main tradenames from several countries containing Anthralin, Dithranol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 226 daltons

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Gottlieb AB, Ryan C, Murase JE. Clinical considerations for the management of psoriasis in women. Int J Womens Dermatol. 2019 Apr 10;5(3):141-150. Abstract Full text (link to original source)
  3. Anthralin Data Sheet 2007 Full text (in our servers)
  4. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  5. Ditranol Ficha técnica 1996 Full text (in our servers)
  6. Goodfield MJ, Hull SM, Cunliffe WJ. The systemic effect of dithranol treatment in psoriasis. Acta Derm Venereol. 1994 Abstract
  7. Selim MM, Goldberg LH, Schaefer H, Bishop SC, Farber EM. Penetration studies of topical anthralin. Br J Dermatol. 1981 Abstract
  8. Schalla W, Bauer E, Schaefer H. Skin permeability of anthralin. Br J Dermatol. 1981 Abstract

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