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Synthetic retinoid derivated from vitamin A. It is a metabolite of etretinate. It is used in the treatment of severe forms of psoriasis, ichthyosis, Darier's disease and lichen planus. Oral administration.
Despite a low amount secreted through the breast milk, less than 2% of the maternal equivalent dose (Rollman 1990), some expert authors (Hale 2019, Butler 2014, Mervic 2014, Schaefer2007, Rollman 1990) think that product's toxicity justifies to avoid it during breastfeeding.
Others consider it compatible with breastfeeding (Briggs 2017). American Academy of Pediatrics: Maternal medication usually compatible with breastfeeding. (AAP 2001)
It can cause gynecomastia. (Atzenhoffer 2018)
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.