Last update: Jan. 15, 2020
Minimal risk for breastfeeding and infant.
An atypical antipsychotic indicated in the treatment of schizophrenia, manic episodes of bipolar disorder and persistent aggression in dementias such as Alzheimer's. Oral administration in two daily doses.
Risperidone and its active metabolite (paliperidone) are excreted in breastmilk in very small amounts (Weggelaar 2011, Aichhorn 2005, Ilett 2004, Hill 2000). No problems have been observed in infants whose mothers were taking it (Aichhorn 2005, Ilett 2004, Ratnayake 2002).
The plasma levels of these infants were undetectable or very low (Weggelaar 2011, Aichhorn 2005, Ilett 2004).
A one-month-old infant whose mother was treated daily with 1.5 mg of risperidone and 0.8 mg of haloperidol had no problems during the first month of life. Sedation and poor nutrition appeared when the dose of haloperidol was increased to 1.5 mg daily (Uguz 2019).
Risperidone frequently causes increased levels of prolactin and galactorrhea (Kc 2018, Pratheesh 2011, Afzal 2007, Holzer 2006, Madhusoodanan 2006, Ilett 2004, Haddad 2004, Kearns 2000, Popli 1998). Some authors have suggested its use as a galactogogue (Parashar 2007).
Expert authors consider this medication to probably be compatible with breastfeeding (Hale 2019, Parikh 2014, Klinger 2013) and preferable to antipsychotics derived from phenothiazine (Rowe 2013), although other alternatives, such as olanzapine or quetiapine, may be preferable (Hale 2019, Pacchiarotti 2016).
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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