Last update June 29, 2022

左米那普仑

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Milnacipran active enantiomer. Serotonin and Norepinephrine selective re-uptake inhibitor antidepressant drug. Oral administration once daily.

Latest update failed to find relevant data on breastfeeding.

Pharmacokinetic data (low serum protein binding and high bioavailability) indicates that drug excretion into breast milk in significant amount is highly probable. Absorption by the infant is likely to be high as well.

Frequent and potential severe side effects have been found.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

  • Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

左米那普仑 is Levomilnacipran Hydrochloride in Chinese.

Is written in other languages:

Groups

左米那普仑 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing 左米那普仑 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 92 %
Molecular weight 283 daltons
Protein Binding 22 %
VD 5.5 - 6.7 l/Kg
Tmax 6 - 8 hours
12 (10 - 20) hours

References

  1. Levomilnacipran. Drug summary. 2013 Full text (in our servers)

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