Last update June 25, 2022

Zuclopenthixol Acetate, Decanoate, Hydrochloride

Compatible

Safe product and/or breastfeeding is the best option.

It is a typical, first generation antipsychotic, with general properties similar to those of chlorpromazine,  that is used for the treatment of schizophrenia and other psychoses. Daily oral administration or intramuscular depot every several days or weeks

It is excreted in breast milk in clinically insignificant amounts (Matheson 1988, Aaes 1986) and no problems have been observed in an infant whose mother was taking it. (Aaes 1986) 

Expert authors consider the use of this medication possible during breastfeeding. (Uguz 2021, Klinger 2013)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

Alternatives

  • Flupentixol (Safe product and/or breastfeeding is the best option.)
  • Olanzapine (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Zuclopenthixol Acetate, Decanoate, Hydrochloride is also known as Zuclopenthixol.


Zuclopenthixol Acetate, Decanoate, Hydrochloride in other languages or writings:

Groups

Zuclopenthixol Acetate, Decanoate, Hydrochloride belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Zuclopenthixol Acetate, Decanoate, Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 40 %
Molecular weight 401 daltons
Protein Binding 99 %
VD 20 l/Kg
pKa 15.59 -
Tmax 4 hours
20 (12 - 28); Depot: 456 hours
M/P ratio 0.3 -
Relative Dose 0.3 %

References

  1. Uguz F. A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation. Am J Ther. 2021 Jan-Feb 01;28(1):e118-e126. Abstract
  2. Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. Abstract
  3. Matheson I, Skjaeraasen J. Milk concentrations of flupenthixol, nortriptyline and zuclopenthixol and between-breast differences in two patients. Eur J Clin Pharmacol. 1988 Abstract
  4. Aaes-Jørgensen T, Bjørndal F, Bartels U. Zuclopenthixol levels in serum and breast milk. Psychopharmacology (Berl). 1986;90(3):417-8. Abstract
  5. Matheson I, Evang A, Overø KF, Syversen G. Presence of chlorprothixene and its metabolites in breast milk. Eur J Clin Pharmacol. 1984;27(5):611-3. Abstract

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