Trimeprimine

It is a tricyclic antidepressant with actions and uses similar to those of amitriptyline. It has marked antimuscarinic and sedative properties. It is used in the treatment of depression. Oral administration in one or two daily doses.

Since the last update we have not found published data on its excretion in breastmilk.

Its high percentage of protein binding, make it highly unlikely that significant quantities will pass into breast milk.

It can cause galactorrhea. ^{(Wolfsperger 2005)}

Somnolence and adequate feeding of the infant should be monitored. Because it can cause sedation and drowsiness, it is not recommended to share a bed (co-sleeping, bed-sharing) with the baby if this medication is being taken, due to increased risk of asphyxia or sudden infant death. ^{(UNICEF 2018, 2017, 2014 and 2013, Landa 2012, ABM 2008, UNICEF 2006)}

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable ^{(Sriraman 2015, Davanzo 2011, ABM 2008)}, especially during the neonatal period and in the event of prematurity.

Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. ^{(Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012)}

 

See below the information of this related product:

• Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)