Last update Dec. 3, 2025

群多普利

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Trandolapril and its active metabolite trandolaprilat are angiotensin converting enzyme inhibitors (ACEI) used in the treatment of hypertension and myocardial infarction. Oral administration every 12 - 24 hours.

At the time of the last update, we found no published data on its excretion in breast milk.

Other compounds in the same group (ACEI) are not significantly excreted in breast milk, but until further published data on this drug in relation to breastfeeding are known safer alternatives may be preferable. (Hale, LactMed, Anderson 2018)

The protective role of breastfeeding against maternal hypertension has been proven. (Park 2018)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

群多普利 is Trandolapril in Chinese.

Is written in other languages:

Groups

群多普利 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing 群多普利 in its composition:

List of 10 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 10 (metab.: 70) %
Molecular weight 431 daltons
Protein Binding 80 %
VD 0.3 l/Kg
pKa 3.8 -
Tmax 4 - 6 hours
T½ 6 (metab.: 24) hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Park S, Choi NK. Breastfeeding and Maternal Hypertension. Am J Hypertens. 2018 Abstract
  4. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  5. AEMPS. Trandolapril. Ficha técnica. 2018 Full text (in our servers)
  6. FDA (Abbott). Trandolapril. Dra Summary. 2011 Full text (in our servers)

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