Last update April 16, 2024

Benazepril Hydrochloride

Compatible

Safe substance and/or breastfeeding is the best option.

Benazepril and its active metabolite benazeprilat are angiotensin converting enzyme inhibitors (ACEI) used in the treatment of hypertension and heart failure. Oral administration every 12-24 hours.

It is excreted in breastmilk in clinically insignificant amounts. (AEMPS 2017, FDA 2015, Frank 2004, Shannon 2000, Kaiser 1989)

No problems have been observed in infants whose mothers were taking other ACEIs (Anderson 2018).

Expert authors consider the use of this drug acceptable during breastfeeding (Hale, LactMed, Briggs 2015).

Due to its potential renal toxicity in premature infants, it is preferable to avoid its use during the neonatal period in case of prematurity. (Serrano 2015)

The protective role of breastfeeding against maternal hypertension has been proven. (Park 2018)

Alternatives

  • Captopril (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Benazepril Hydrochloride in other languages or writings:

Tradenames

Main tradenames from several countries containing Benazepril Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 37 %
Molecular weight 461 daltons
Protein Binding 95 %
VD 0.124 l/Kg
pKa 3.53 -
Tmax 1.5 - 4 hours
11 hours
M/P ratio 0.01 -
Theoretical Dose 0.0003 mg/Kg/d
Relative Dose 0.09 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  4. Park S, Choi NK. Breastfeeding and Maternal Hypertension. Am J Hypertens. 2018 Abstract
  5. AEMPS. Benazepril. Ficha técnica. 2017 Full text (in our servers)
  6. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source)
  7. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract
  8. FDA -Validus Pharm. Benazepril. Drug Summary. 2015 Full text (in our servers)
  9. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  10. Frank J Nice, Deborah DeEugenio, Traci A DiMino, Ingrid C Freeny, Marissa B Rovnack, and Joseph S Gromelski. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and other Healthcare Professionals Part II. Journal of Pharmacy Technology 20 (2), 85-95 2004 Full text (link to original source) Full text (in our servers)
  11. Shannon ME, Malecha SE, Cha AJ. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) and lactation: an update. J Hum Lact. 2000 Abstract
  12. Kaiser G, Ackerman R, Dieterle W, Fleiss PM. Benazepril and benazeprilat in human plasma and breast milk (abstract). Eur J Clin Pharmacol 1989;36(Suppl): page 303, poster 14.14. 1989

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