Last update July 31, 2018

Lisinopril

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Lisinopril is an angiotensin-converting enzyme inhibitor (ACEI) used in the treatment of hypertension, heart failure and diabetic nephropathy and as prophylaxis after myocardial infarction.
Oral administration once a day.

Since the last update we have not found published data on its excretion in breastmilk.

Other compounds from the same group (ACEI) are not excreted in breastmilk in significant amounts, but until there is more information about this drug in relation to breastfeeding, safer known alternatives are preferable, especially during the neonatal period and in case of prematurity. (Anderson 2018, Hale 2017 p567, Malachias 2016, AEMPS 2017).

The protective role of breastfeeding against maternal hypertension has been proven (Park 2018)

Alternatives

  • Captopril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Enalapril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Lisinopril in other languages or writings:

Group

Lisinopril belongs to this group or family:

Tradenames

Main tradenames from several countries containing Lisinopril in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 (6 - 60) %
Molecular weight 442 daltons
Protein Binding 0 %
pKa 3.17 -
Tmax 7 hours
T½ 12.6 hours

References

  1. Park S, Choi NK. Breastfeeding and Maternal Hypertension. Am J Hypertens. 2018 Abstract
  2. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  3. AEMPS. Lisinopril. Ficha técnica. 2017 Full text (in our servers)
  4. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. Astra-Zeneca. Lisinopril. Drug Summary. 2012 Full text (in our servers)

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