Last update Aug. 24, 2022

Plasma Thromboplastin Component; PTC

Compatible

Safe substance and/or breastfeeding is the best option.

Coagulation factor IX is a plasma glycoprotein consisting of 415 amino acids that is used to treat hemophilia B (Christmas disease, factor IX deficiency). It can be obtained from human plasma or produced by recombinant DNA technology (albutrepenonacog alfa, eftrenonacog alfa), as glycosylated forms (Nonacog alpha or gamma), or as a pegylated derivative (nonacog beta pegol). Intravenous administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its very high molecular weigh make it highly unlikely that significant quantities will pass into breast milk.

Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant, except in premature babies and the immediate neonatal period, when there may be greater intestinal permeability.

Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)

Alternatives

We do not have alternatives for Plasma Thromboplastin Component; PTC since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Plasma Thromboplastin Component; PTC is also known as Coagulation Factor IX. Here it is a list of alternative known names::


Plasma Thromboplastin Component; PTC in other languages or writings:

Group

Plasma Thromboplastin Component; PTC belongs to this group or family:

Tradenames

Main tradenames from several countries containing Plasma Thromboplastin Component; PTC in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 46.548 daltons
T½ 18.8 ± 5.4 hours

References

  1. AEMPS. Factor IX. Ficha técnica. 2017 Full text (in our servers)
  2. Pfizer. Factor IX. Drug Summary. 2017 Full text (in our servers)
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)

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