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Coagulation factor IX is a plasma glycoprotein consisting of 415 amino acids that is used to treat hemophilia B (Christmas disease, factor IX deficiency). It can be obtained from human plasma or produced by recombinant DNA technology (albutrepenonacog alfa, eftrenonacog alfa), as glycosylated forms (Nonacog alpha or gamma), or as a pegylated derivative (nonacog beta pegol). Intravenous administration.
Since the last update we have not found published data on its excretion in breastmilk.
Its very high molecular weigh make it highly unlikely that significant quantities will pass into breast milk.
Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant, except in premature babies and the immediate neonatal period, when there may be greater intestinal permeability.
Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)