Last update Aug. 24, 2022
Very Low Risk
We do not have alternatives for Nonacog alfa. Nonacog Gamma since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Nonacog alfa. Nonacog Gamma is also known as Coagulation Factor IX. Here it is a list of alternative known names::
Nonacog alfa. Nonacog Gamma in other languages or writings:
Nonacog alfa. Nonacog Gamma belongs to this group or family:
Main tradenames from several countries containing Nonacog alfa. Nonacog Gamma in its composition:
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Coagulation factor IX is a plasma glycoprotein consisting of 415 amino acids that is used to treat hemophilia B (Christmas disease, factor IX deficiency). It can be obtained from human plasma or produced by recombinant DNA technology (albutrepenonacog alfa, eftrenonacog alfa), as glycosylated forms (Nonacog alpha or gamma), or as a pegylated derivative (nonacog beta pegol). Intravenous administration.
Since the last update we have not found published data on its excretion in breastmilk.
Its very high molecular weigh make it highly unlikely that significant quantities will pass into breast milk.
Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant, except in premature babies and the immediate neonatal period, when there may be greater intestinal permeability.
Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)