Last update June 29, 2022
It is an antidepressant structurally related to trazodone. Oral administration in two daily doses.
Its pharmacokinetic data (high percentage of protein binding, large volume of distribution and moderately high molecular weight) explain the negligible passage into breast milk observed. (Yapp 2000, Dodd 2000 & 1999)
However, a 9-week-old, 27-week-premature infant whose mother was taking nefazodone had drowsiness, lethargy, growth retardation, and hypothermia. (Gjerdingen 2003, Yapp 2000)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Davanzo 2011), especially during the neonatal period and in the event of prematurity.
Withdrawn from market in many countries because an increased risk of a rather rare but severe hepatotoxicity. (Choi 2003)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.