Last update May 20, 2024

モキソニジン

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

A centrally-acting antihypertensive and antiadrenergic agent structurally related to clonidine. Indicated in the treatment of hypertension. Oral administration once a day.

Its pharmacokinetic data - low plasma protein binding and low molecular weight (Kirsten 1998) - may possibly explain the excretion in breastmilk observed, whose amount could affect the infant. (Schaefer 2015 p716, Schaefer 1998).

Moxonidine does not cause alterations in the secretion of prolactin.. (Bamberger 1995)

Until there is more published data on this drug in relation to breastfeeding (Schaefer 2015 p717), safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.

Alternatives

  • Labetalol Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Methyldopa (Safe substance and/or breastfeeding is the best option.)
  • Metoprolol (Safe substance and/or breastfeeding is the best option.)
  • Nifedipine (Safe substance and/or breastfeeding is the best option.)
  • Nimodipine (Safe substance and/or breastfeeding is the best option.)
  • Propranolol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

モキソニジン is Moxonidine in Japanese.

Is written in other languages:

Groups

モキソニジン belongs to these groups or families:

Tradenames

Main tradenames from several countries containing モキソニジン in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 88 %
Molecular weight 242 daltons
Protein Binding 7 %
VD 1.8 ± 0.4 l/Kg
pKa 7.26 -
Tmax 0.5 - 3 hours
T½ 2 - 3 hours
M/P ratio 1 - 2 -
Theoretical Dose 0.0004 mg/Kg/d
Relative Dose 12.1 %

References

  1. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  2. Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998 Abstract
  3. Schaefer HG, Toublanc N, Weimann HJ. The pharmacokinetics of moxonidine. Rev Contemp Pharmacother 1998; 9: 481–90. 1998
  4. Bamberger CM, Mönig H, Mill G, Gödde E, Schulte HM. Growth hormone secretion in response to the new centrally acting antihypertensive agent moxonidine in normal human subjects: comparison to clonidine and GHRH. Exp Clin Endocrinol Diabetes. 1995 Abstract

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