Last update July 17, 2022

Indacaterol Maleate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Indacaterol is an inhaled long-acting beta2 adrenergic agonist used as a bronchodilator in the maintenance treatment of chronic obstructive pulmonary disease and moderate to severe asthma. Inhaled administration once daily.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Terbutaline which is a compound closely related to Formoterol is excreted into breast milk in non-significant amount. Salmeterol, another compound with similar characteristics, is also non-significantly excreted. 

Its low oral bioavailability would hamper the pass to the infant’s plasma through the breastmilk ingested.



Several medical societies, experts authors and expert consensus consider the use of inhaled bronchodilators to be safe during breastfeeding. (Amir 2011, National Asthma 2004, Nelson 2001, Ellsworth 1994).

Alternatives

We do not have alternatives for Indacaterol Maleate.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Indacaterol Maleate is also known as Indacaterol.


Indacaterol Maleate in other languages or writings:

Group

Indacaterol Maleate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Indacaterol Maleate in its composition:

  • Enerzair™. Contains other elements than Indacaterol Maleate in its composition
  • Enstrux™. Contains other elements than Indacaterol Maleate in its composition
  • Hirobriz
  • Onbrez
  • Onbrize
  • Oslif
  • Ultibro™. Contains other elements than Indacaterol Maleate in its composition
  • Ulunar™. Contains other elements than Indacaterol Maleate in its composition
  • Xoterna™. Contains other elements than Indacaterol Maleate in its composition
  • Zimbus™. Contains other elements than Indacaterol Maleate in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. inhal: 45; oral 23 %
Molecular weight 393 daltons
Protein Binding 95 %
VD 36.5 l/Kg
pKa 8.51 -
40 - 56 hours

References

  1. Novartis. Indacaterol. Drug Summary. 2021 Full text (in our servers)
  2. Novartis. Indacaterol. Ficha técnica. 2014 Full text (in our servers)
  3. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  4. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  5. Nelson-Piercy C. Asthma in pregnancy. Thorax. 2001 Abstract Full text (link to original source) Full text (in our servers)
  6. Ellsworth A. Pharmacotherapy of asthma while breastfeeding. J Hum Lact. 1994 Abstract

Total visits

693

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM