Last update July 20, 2017

Salmeterol

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Long-acting bronchodilator.



At latest update no published data on excretion into breastmilk were found.



Because of a high plasma protein-binding capacity and very low or undetectable plasma concentrations observed after inhalation (Cazzola 2002, AEMPS 2012) the excretion into breastmilk in significant amounts is unlikely.

Its low oral bioavailability would hamper the pass to the infant’s plasma through the breastmilk ingested.



Experts and scientific societies consider the use of Salmeterol during breastfeeding as devoid of risk for the infant (Ellsworth 1994, McDonald 1996, Nelson 2001, National Asthma Education 2004).



Terbutaline (see specific info), a molecule related to the same group of drugs, is excreted in non-significant amounts into breastmilk.


See below the information of this related product:

Alternatives

We do not have alternatives for Salmeterol since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Salmeterol is also known as


Salmeterol in other languages or writings:

Group

Salmeterol belongs to this group or family:

Tradenames

Main tradenames from several countries containing Salmeterol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja - poor %
Molecular weight 604 daltons
Protein Binding 98 %
Tmax 0,1 - 0,75 hours
T1/2 5,5 hours
M/P ratio 1 -

References

  1. PDR.net Fluticasone-Salmeterol Drug Summary 2013 Full text (in our servers)
  2. AEMPS. Salmeterol. Ficha técnica. 2012 Full text (in our servers)
  3. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  4. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. 2004 Full text (link to original source) Full text (in our servers)
  5. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  6. Cazzola M, Testi R, Matera MG. Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet. 2002 Abstract
  7. Nelson-Piercy C. Asthma in pregnancy. Thorax. 2001 Abstract Full text (link to original source) Full text (in our servers)
  8. Ellsworth A. Pharmacotherapy of asthma while breastfeeding. J Hum Lact. 1994 Abstract

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