Last update Aug. 23, 2022

Dinoprost trometamol

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Dinoprost or Prostaglandin F2α is used for termination of pregnancy and missed miscarriage, hydatidiform mole, and intra-uterine fetal death. It has a higher incidence of adverse effects than dinoprostone and is therefore not recommended for labor induction. It is administered intraamniotically.

Since the last update we have not found published data on its excretion in breastmilk.

Its very rapid elimination from plasma make it highly unlikely that significant quantities will pass into breast milk.

It is a natural component of breast milk (Shimizu 1992, Neu 1988, Alzina 1986, Friedman 1986, Lucas 1980) that changes concentration during breastfeeding. (Ylikorkala 1981). Prostaglandins in breast milk can protect the integrity of gastro-intestinal epithelial cells in infants. (Bedrick 1989)

Alternatives

  • Dinoprostone (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Misoprostol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Dinoprost trometamol is also known as


Dinoprost trometamol in other languages or writings:

Group

Dinoprost trometamol belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dinoprost trometamol in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 476 daltons
T½ < 0.1 hours

References

  1. Shimizu T, Yamashiro Y, Yabuta K. Prostaglandin E1, E2, and F2 alpha in human milk and plasma. Biol Neonate. 1992 Abstract
  2. Bedrick AD, Britton JR, Johnson S, Koldovský O. Prostaglandin stability in human milk and infant gastric fluid. Biol Neonate. 1989;56(4):192-7. Abstract
  3. Neu J, Wu-Wang CY, Measel CP, Gimotty P. Prostaglandin concentrations in human milk. Am J Clin Nutr. 1988 Abstract
  4. Friedman Z. Prostaglandins in breast milk. Endocrinol Exp. 1986 Aug;20(2-3):285-91. Abstract
  5. Ylikorkala O, Viinikka L. Prostacyclin, thromboxane, and prostaglandin F2 alpha in maternal plasma during breast-feeding. Am J Obstet Gynecol. 1981 Mar 15;139(6):690-2. Abstract
  6. Lucas A, Mitchell MD. Prostaglandins in human milk. Arch Dis Child. 1980 Abstract

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