Last update Aug. 23, 2022

地诺前列素

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Dinoprost or Prostaglandin F is used for termination of pregnancy and missed miscarriage, hydatidiform mole, and intra-uterine fetal death. It has a higher incidence of adverse effects than dinoprostone and is therefore not recommended for labor induction. It is administered intraamniotically.

Since the last update we have not found published data on its excretion in breastmilk.

Its very rapid elimination from plasma make it highly unlikely that significant quantities will pass into breast milk.

It is a natural component of breast milk (Shimizu 1992, Neu 1988, Alzina 1986, Friedman 1986, Lucas 1980) that changes concentration during breastfeeding. (Ylikorkala 1981). Prostaglandins in breast milk can protect the integrity of gastro-intestinal epithelial cells in infants. (Bedrick 1989)

Alternatives

  • Dinoprostone (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Misoprostol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

地诺前列素 belongs to this group or family:

Tradenames

Main tradenames from several countries containing 地诺前列素 in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 476 daltons
< 0.1 hours

References

  1. Shimizu T, Yamashiro Y, Yabuta K. Prostaglandin E1, E2, and F2 alpha in human milk and plasma. Biol Neonate. 1992 Abstract
  2. Bedrick AD, Britton JR, Johnson S, Koldovský O. Prostaglandin stability in human milk and infant gastric fluid. Biol Neonate. 1989;56(4):192-7. Abstract
  3. Neu J, Wu-Wang CY, Measel CP, Gimotty P. Prostaglandin concentrations in human milk. Am J Clin Nutr. 1988 Abstract
  4. Friedman Z. Prostaglandins in breast milk. Endocrinol Exp. 1986 Aug;20(2-3):285-91. Abstract
  5. Ylikorkala O, Viinikka L. Prostacyclin, thromboxane, and prostaglandin F2 alpha in maternal plasma during breast-feeding. Am J Obstet Gynecol. 1981 Mar 15;139(6):690-2. Abstract
  6. Lucas A, Mitchell MD. Prostaglandins in human milk. Arch Dis Child. 1980 Abstract

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