Last update Aug. 6, 2017


Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Usually used in combination with sofosbuvir in the treatment of hepatitis C.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (high molecular weight and very high percentage of protein binding) make it very unlikely that significant amounts would pass into breast milk, therefore it would not be necessary to stop breastfeeding when taking this medication on its own or in combination with sofosbuvir (Lactmed 2016).

See below the information of these related products:

  • Maternal Hepatitis C Infection ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Sofosbuvir (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C49H54N8O8 is Velpatasvir in Molecular formula.

Is written in other languages:


C49H54N8O8 belongs to this group or family:


Main tradenames from several countries containing C49H54N8O8 in its composition:

  • Epclusa™. Contains other elements than C49H54N8O8 in its composition


Variable Value Unit
Molecular weight 883 daltons
Protein Binding 99.6 %
Tmax 3 hours
15 hours


  1. Smolders EJ, Jansen AME, Ter Horst PGJ, Rockstroh J, Back DJ, Burger DM. Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations: A 2019 Update. Clin Pharmacokinet. 2019 Oct;58(10):1237-1263. Abstract
  2. EMA. Sofosbuvir/Velpatasvir (Epclusa). Ficha técnica. 2017 Full text (in our servers)
  3. EMA. Sofosbuvir/Velpatasvir (Epclusa). Drug Summary. 2017 Full text (in our servers)
  4. LactMed. Velpatasvir. Full Record Display. 2016 Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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