Last update Aug. 6, 2017

Sofosbuvir

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Usually used in combination with Ledispavir in the treatment of hepatitis C.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (moderately elevated molecular weight, good percentage of protein binding and very short half-life) impedes its passage to breast milk in significant amounts, so although there is disagreement (Thompson 2016), some authors consider that treatment with sofosbuvir, alone or in combination with ledipasvir is not contraindicated during breastfeeding (Spera 2016).


See below the information of these related products:

  • Ledipasvir (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Maternal Hepatitis C Infection ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sofosbuvir in other languages or writings:

Group

Sofosbuvir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Sofosbuvir in its composition:

  • Epclusa™. Contains other elements than Sofosbuvir in its composition
  • Harvoni™. Contains other elements than Sofosbuvir in its composition
  • Sovaldi

Pharmacokinetics

Variable Value Unit
Molecular weight 530 daltons
Protein Binding 60 - 85 %
Tmax 0,5 - 2 hours
T1/2 0,5 hours

References

  1. Smolders EJ, Jansen AME, Ter Horst PGJ, Rockstroh J, Back DJ, Burger DM. Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations: A 2019 Update. Clin Pharmacokinet. 2019 Oct;58(10):1237-1263. Abstract
  2. EMA. Sofosbuvir (Sovaldi). Drug Summary. 2017 Full text (in our servers)
  3. EMA. Ledipasvir/Sofosbuvir (Harvoni). Ficha técnica. 2017 Full text (in our servers)
  4. EMA. Ledipasvir/Sofosbuvir (Harvoni). Drug Summary. 2017 Full text (in our servers)
  5. EMA. Sofosbuvir/Velpatasvir (Epclusa). Ficha técnica. 2017 Full text (in our servers)
  6. EMA. Sofosbuvir/Velpatasvir (Epclusa). Drug Summary. 2017 Full text (in our servers)
  7. EMA. Sofosbuvir (Sovaldi). Ficha técnica. 2017 Full text (in our servers)
  8. Thompson AJ. Australian recommendations for the management of hepatitis C virus infection: a consensus statement. Med J Aust. 2016 Abstract Full text (link to original source) Full text (in our servers)
  9. Spera AM, Eldin TK, Tosone G, Orlando R. Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women? World J Hepatol. 2016 Abstract Full text (link to original source) Full text (in our servers)

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