Last update Aug. 6, 2017

Ledipasvir

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Usually used in combination with sofosbuvir in the treatment of hepatitis C.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (high molecular weight and very high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into breast milk, so that, although there is disagreement (Thompson 2016), some authors consider that treatment with ledispavir, alone or in combination with sofosbuvir is not contraindicated during breastfeeding (Spera 2016).


See below the information of these related products:

  • Maternal Hepatitis C Infection (Safe substance and/or breastfeeding is the best option.)
  • Sofosbuvir (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Ledipasvir in other languages or writings:

Group

Ledipasvir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ledipasvir in its composition:

  • Harvoni™. Contains other elements than Ledipasvir in its composition

Pharmacokinetics

Variable Value Unit
Molecular weight 889 daltons
Protein Binding 99.9 %
Tmax 4 hours
T½ 47 hours

References

  1. Smolders EJ, Jansen AME, Ter Horst PGJ, Rockstroh J, Back DJ, Burger DM. Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations: A 2019 Update. Clin Pharmacokinet. 2019 Oct;58(10):1237-1263. Abstract
  2. EMA. Ledipasvir/Sofosbuvir (Harvoni). Ficha técnica. 2017 Full text (in our servers)
  3. EMA. Ledipasvir/Sofosbuvir (Harvoni). Drug Summary. 2017 Full text (in our servers)
  4. Thompson AJ. Australian recommendations for the management of hepatitis C virus infection: a consensus statement. Med J Aust. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. Spera AM, Eldin TK, Tosone G, Orlando R. Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women? World J Hepatol. 2016 Abstract Full text (link to original source) Full text (in our servers)

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