Last update Aug. 6, 2017

Velpatasvir

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Usually used in combination with sofosbuvir in the treatment of hepatitis C.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (high molecular weight and very high percentage of protein binding) make it very unlikely that significant amounts would pass into breast milk, therefore it would not be necessary to stop breastfeeding when taking this medication on its own or in combination with sofosbuvir (Lactmed 2016).


See below the information of these related products:

  • Maternal Hepatitis C Infection (Safe substance and/or breastfeeding is the best option.)
  • Sofosbuvir (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Velpatasvir in other languages or writings:

Group

Velpatasvir belongs to this group or family:

Tradenames

Main tradenames from several countries containing Velpatasvir in its composition:

  • Epclusa™. Contains other elements than Velpatasvir in its composition

Pharmacokinetics

Variable Value Unit
Molecular weight 883 daltons
Protein Binding 99.6 %
Tmax 3 hours
T½ 15 hours

References

  1. Smolders EJ, Jansen AME, Ter Horst PGJ, Rockstroh J, Back DJ, Burger DM. Viral Hepatitis C Therapy: Pharmacokinetic and Pharmacodynamic Considerations: A 2019 Update. Clin Pharmacokinet. 2019 Oct;58(10):1237-1263. Abstract
  2. EMA. Sofosbuvir/Velpatasvir (Epclusa). Ficha técnica. 2017 Full text (in our servers)
  3. EMA. Sofosbuvir/Velpatasvir (Epclusa). Drug Summary. 2017 Full text (in our servers)
  4. LactMed. Velpatasvir. Full Record Display. 2016 Full text (in our servers)

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