Last update: Aug. 14, 2020


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Propafenone is a class Ic antiarrhythmic with some negative inotropic and beta-adrenoceptor blocking activity.
It is used in the management of supraventricular and ventricular arrhythmias.
Oral administration three times a day.

It is excreted in breast milk in clinically insignificant amounts (Wakaumi 2005, Libaron 1991).

In people who are slow metabolisers, the elimination half-life can be 10 to 32 hours.

Expert authors consider the use of the medication to be probably compatible during breastfeeding (Hale 2019, Briggs 2017).


We do not have alternatives for プロパフェノン塩酸塩 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

プロパフェノン塩酸塩 is Propafenone Hydrochloride in Japanese.

Is written in other languages:

プロパフェノン塩酸塩 is also known as


プロパフェノン塩酸塩 belongs to this group or family:


Main tradenames from several countries containing プロパフェノン塩酸塩 in its composition:


Variable Value Unit
Oral Bioavail. 5 - 50 %
Molecular weight 378 daltons
Protein Binding 97 %
VD 3,6 l/Kg
pKa 14,1 -
Tmax 2 - 3 hours
T1/2 2 - 10 hours
M/P ratio 0,15 - 0,25 -
Theoretical Dose 0,007 - 0,012 mg/Kg/d
Relative Dose 0,03 - 0,1 %


  1. GSK. Propafenone. Drug Summary. 2018 Full text (in our servers)
  2. Accord H. Propafenona. Ficha técnica. 2017 Full text (in our servers)
  3. Wakaumi M, Tsuruoka S, Sakamoto K, Shiga T, Fujimura A. Pilsicainide in breast milk from a mother: comparison with disopyramide and propafenone. Br J Clin Pharmacol. 2005 Jan;59(1):120-2. No abstract available. Abstract Full text (link to original source) Full text (in our servers)
  4. Libardoni M, Piovan D, Busato E, Padrini R. Transfer of propafenone and 5-OH-propafenone to foetal plasma and maternal milk. Br J Clin Pharmacol. 1991 Oct;32(4):527-8. No abstract available. Abstract Full text (link to original source) Full text (in our servers)

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