Last update: Aug. 14, 2020

προπαφαινόνη υδοχλωρική

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Propafenone is a class Ic antiarrhythmic with some negative inotropic and beta-adrenoceptor blocking activity.
It is used in the management of supraventricular and ventricular arrhythmias.
Oral administration three times a day.

It is excreted in breast milk in clinically insignificant amounts (Wakaumi 2005, Libaron 1991).

In people who are slow metabolisers, the elimination half-life can be 10 to 32 hours.

Expert authors consider the use of the medication to be probably compatible during breastfeeding (Hale 2019, Briggs 2017).

Alternatives

We do not have alternatives for προπαφαινόνη υδοχλωρική since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

προπαφαινόνη υδοχλωρική is Propafenone Hydrochloride in Greek.

Is written in other languages:

προπαφαινόνη υδοχλωρική is also known as

Group

προπαφαινόνη υδοχλωρική belongs to this group or family:

Tradenames

Main tradenames from several countries containing προπαφαινόνη υδοχλωρική in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 5 - 50 %
Molecular weight 378 daltons
Protein Binding 97 %
VD 3,6 l/Kg
pKa 14,1 -
Tmax 2 - 3 hours
T1/2 2 - 10 hours
M/P ratio 0,15 - 0,25 -
Theoretical Dose 0,007 - 0,012 mg/Kg/d
Relative Dose 0,03 - 0,1 %

References

  1. GSK. Propafenone. Drug Summary. 2018 Full text (in our servers)
  2. Accord H. Propafenona. Ficha técnica. 2017 Full text (in our servers)
  3. Wakaumi M, Tsuruoka S, Sakamoto K, Shiga T, Fujimura A. Pilsicainide in breast milk from a mother: comparison with disopyramide and propafenone. Br J Clin Pharmacol. 2005 Jan;59(1):120-2. No abstract available. Abstract Full text (link to original source) Full text (in our servers)
  4. Libardoni M, Piovan D, Busato E, Padrini R. Transfer of propafenone and 5-OH-propafenone to foetal plasma and maternal milk. Br J Clin Pharmacol. 1991 Oct;32(4):527-8. No abstract available. Abstract Full text (link to original source) Full text (in our servers)

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