Last update: July 31, 2018


Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

An alkaloid derived from the opium of the Papaver somniferum plant or prepared synthetically. Not structurally related to the rest of opium alkaloids such as morphine or codeine.
It has a relaxant effect on the vascular system, bronchial musculature and the gastrointestinal, biliary and urinary tracts (American Regent 2017).
Indicated in coronary, pulmonary, peripheral or cerebral vascular spasms and gastrointestinal, ureteral or biliary colic. Oral, intramuscular or intravenous administration every 3 to 12 hours.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (large volume of distribution, high percentage of protein binding, short half-life, pKa acid) make transfer to milk in significant quantities unlikely.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Papaverine is also known as

Papaverine in other languages or writings:


Main tradenames from several countries containing Papaverine in its composition:

  • Antipasmol™. Contains other elements than Papaverine in its composition
  • Atroveran Composto™. Contains other elements than Papaverine in its composition
  • Bo Wei (泊威)
  • Buton™. Contains other elements than Papaverine in its composition
  • Colicor™. Contains other elements than Papaverine in its composition
  • Dipatropin™. Contains other elements than Papaverine in its composition
  • Dolospam™. Contains other elements than Papaverine in its composition
  • Fei Lin (菲林)
  • Mesotina


Variable Value Unit
Oral Bioavail. 28 (5 - 99) %
Molecular weight 339 daltons
Protein Binding 90 - 95 %
VD 3,1 l/Kg
pKa 6,03 -
Tmax 2,5 hours
T1/2 0,5 - 2, 2 hours


  1. American Regent. Papaverine. Drug Summary. 2017 Full text (in our servers)
  2. AcoFarma. Papaverina. Ficha técnica. 2010 Full text (in our servers)
  3. Berg G, Jönsson KA, Hammar M, Norlander B. Variable bioavailability of papaverine. Pharmacol Toxicol. 1988 Abstract
  4. Wilén G, Ylitalo P. Metabolism of [14C] papaverine in man. J Pharm Pharmacol. 1982 Abstract Full text (link to original source)
  5. Garrett ER, Roseboom H, Green JR Jr, Schuermann W. Pharmacokinetics of papaverine hydrochloride and the biopharmaceutics of its oral dosage forms. Int J Clin Pharmacol Biopharm. 1978 Abstract
  6. Ritschel WA, Hammer GV. Pharmacokinetics of papaverine in man. Int J Clin Pharmacol Biopharm. 1977 Abstract

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