Last update: June 12, 2019

Oxymetazoline Hydrochloride

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Sympathomimetic drug that is topically used for treatment of nose or the eye.

A fecha de última actualización no encontramos datos publicados en relación con la lactancia.

A small dose together with a low plama level of most nasal and ophthalmologic compounds make that a significant excretion into breast milk would be unlikely.

Avoid over dosage and do not use it for longer than 3 days: as any other adrenergic-agonist drug, when absorbed, it may be a cause of side effects (vascular hyper-hypotension, irritability, heart arrhythmia) on both the mother and the infant.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

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Other names

Oxymetazoline Hydrochloride is also known as


Oxymetazoline Hydrochloride in other languages or writings:

Groups

Oxymetazoline Hydrochloride belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Molecular weight 297 daltons
Protein Binding 57 %
pKa 10,9 -
Tmax 0,1 - 0,2 hours
T1/2 5,2 hours

References

  1. Cartabuke RS, Anderson BJ, Elmaraghy C, Rice J, Tumin D, Tobias JD. Hemodynamic and pharmacokinetic analysis of oxymetazoline use during nasal surgery in children. Laryngoscope. 2019 Feb 20. Abstract
  2. Kuang AW, DuBois J, Attar M, Ahluwalia G. Clinical Pharmacokinetics of Oxymetazoline Cream Following Topical Facial Administration for the Treatment of Erythema Associated With Rosacea. J Drugs Dermatol. 2018 Feb 1;17(2):213-220. Abstract
  3. Redaction Prescrire. Pour mieux soigner, des médicaments à écarter : bilan 2018. Prescrire.org. 2018 Full text (link to original source) Full text (in our servers)
  4. Allergan. Oximetazoline Cream (Rhode). Drug Summary. 2017 Full text (in our servers)
  5. Cacek AT, Gobburu JV, Gopalakrishnan M. Population Pharmacokinetics of an Intranasally Administered Combination of Oxymetazoline and Tetracaine in Healthy Volunteers. J Clin Pharmacol. 2017 Feb;57(2):247-254. Abstract
  6. FDA. Tetracaine and Oxymetazoline Drug Summary. 2016 Full text (in our servers)
  7. Giannakopoulos H, Levin LM, Chou JC, Cacek AT, Hutcheson M, Secreto SA, Moore PA, Hersh EV. The cardiovascular effects and pharmacokinetics of intranasal tetracaine plus oxymetazoline: preliminary findings. J Am Dent Assoc. 2012 Aug;143(8):872-80. Abstract
  8. Pharmex. Oximetazolina. Ficha técnica. 2009 Full text (in our servers)
  9. Anderson PO. Decongestants and milk production. J Hum Lact. 2000 Abstract
  10. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract

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