Last update: May 11, 2019
Not risky for breastfeeding or infant.
Fluoroquinolone with bactericidal effect by inhibition of bacterial DNA synthesis.
Oral or intravenous administration twice a day.
Both ofloxacin and its isomer, levofloxacin, are excreted in tiny amounts into breast milk (Cahill 2005, Zhang 1997, Giamarellou 1989).
No problems attributable to ofloxacin have been observed in infants whose mothers took it (Drobac 2005).
Structurally similar Quinolone-related medication has been used in neonates and infants without known side effects (Newby 2017, Dutta 2006, Belet 2004, Drossou 2004, Chin 2001, van den Oever 1998, Gürpinar 1997). It is excreted in tiny amounts into breast milk and absorption through the child’s gut may be interfered by calcium in the milk (Fleiss 1992, Neuvonen 1991).
Should it be prescribed to a nursing mother Norfloxacine, Ofloxacine and Ciprofloxacine are to be chosen since they have shown a lowest excretion into the milk (Butler 2014).
The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account,
Various medical societies and expert consensus consider the use of this medication safe during breastfeeding (Briggs 2017, Hale 2017 p721, Nahum 2006).
American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).
Unreasonably prolonged or repetitive use of antibiotics is harmful to health.
Due to the publication of reports of serious or potentially serious side effects in patients treated with fluoroquinolones, several health authorities propose restricting their indiscriminate outpatient use and reserving them for certain serious diseases (EMA 2018, FDA 2016, Arbex 2010).
The small dose and poor plasma uptake of most topical ophthalmologic preparations make it very unlikely that significant amounts will pass into breast milk.
We do not have alternatives for Ofloxacin since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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