Last update: Sept. 28, 2014

Nitrofurantoin

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Excretion into breast milk is clinically non-significant with no side-effects observed among breastfed infants from treated mothers except rare cases of diarrhea.

Do not use while the infant is younger of two weeks of age or suffers of G-6-P dehydrogenase deficiency to avoid likelihood of hemolysis.

Be aware of false negative results that may be obtained from febrile infants with bacterial cultures when the mother is on antibiotics. Also, the possibility of developing diarrhea due to bacterial flora imbalance.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Nitrofurantoin is also known as


Group

Nitrofurantoin belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 238 daltons
Protein Binding 60 - 90 %
Tmax 1,5 - 5 hours
T1/2 0,3 - 1 hours
M/P ratio 0,3 - 6 -
Theoretical Dose 0,075 - 0,41 mg/Kg/d
Relative Dose 1 - 6 %
Relat.Ped.Dose 1 - 6 %

References

  1. Zao J, Koren G, Bozzo P. Using nitrofurantoin while breastfeeding a newborn. Can Fam Physician. 2014 Abstract Full text (link to original source) Full text (in our servers)
  2. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract Full text (link to original source) Full text (in our servers)
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  4. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  5. Gerk PM, Kuhn RJ, Desai NS, McNamara PJ. Active transport of nitrofurantoin into human milk. Pharmacotherapy. 2001 Abstract
  6. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  7. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  8. Pons G, Rey E, Richard MO, Vauzelle F, Francoual C, Moran C, d'Athis P, Badoual J, Olive G. Nitrofurantoin excretion in human milk. Dev Pharmacol Ther. 1990 Abstract
  9. Varsano I, Fischl J, Shochet SB. The excretion of orally ingested nitrofurantoin in human milk. J Pediatr. 1973 Abstract
  10. Hosbach RH, Foster RB. Absence of nitrofurantoin from human milk. JAMA. 1967 Abstract

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