Last update: July 2, 2015


Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Excretion into breast milk is low (even lower when administered through Epidural Anesthesia).

In addition, a low oral bioavailability makes that the amount present in the infant's plasma due to absorption from milk by the gut is low.

Even though, level of drug has been found in the plasma of infants from treated mothers, harmful effects in the infants were not reported.

Levels in the milk are lower and side-effects are fewer among infants whose mothers were treated with Morphine than with Pethidine.

Some authorities consider Morphine as the elective opioid medication for breastfeeding mothers.

Analgesia used during the birth process is related to a brief delayed of stage II of Lactogenesis (milk come-in).

Morphine increases Prolactin level and may decrease Oxytocin level, but it would not be determinant for already established lactations.

Avoidance of repetitive or chronic use and follow-up for somnolence and adequacy of infant nourishment is recommended.

Bed-sharing should be avoid whenever this medication is used by parents.

The American Academy of Pediatrics rates it as compatible with breastfeeding.


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Morphine in other languages or writings:


Variable Value Unit
Oral Bioavail. 39 %
Molecular weight 285 daltons
Protein Binding 35 %
Tmax 1 hours
T1/2 2 hours
M/P ratio 5,1 -
Theoretical Dose 0,075 mg/Kg/d
Relative Dose 2,5 - 7,5 %
Relat.Ped.Dose 2,5 - 6,3 %


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