Last update: Feb. 14, 2020

Maternal Cystic Fybrosis

Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
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Improvements in the treatment and management of this disease have increased life expectancy, allowing patients to reach the reproductive stage and in women, unlike men, fertility is not greatly affected (Kroon 2018, McGuire 2016, Festini 2006).

Exclusive or partial breastfeeding should be encouraged, taking into account the health conditions of each mother (McGuire 2016, Edenborough 2008, Michel 1994, Kent 1993, Stead 1987). Partial breastfeeding of twins has been recorded (McGuire 2016).
It requires a great deal of support, monitoring of the weight and health status of the mother with an extra daily intake of 500 calories, 11 g of protein, 500 mg of calcium, 400 IU of vitamin D and 2 litres of water (Edenborough 2008, Michel 1994).
Respiratory physiotherapy must take into account changes in the breasts (Edenborough 2008).

The concentration of sodium and other electrolytes and proteins in breastmilk are normal; linoleic acid, arachidonic acid and cholesterol levels are slightly decreased (McGuire 2016, Edenborough 2008, Kent 1993, Hamosh 1992, Shiffman 1989, Bitman 1987, Stead 1987, Alpert 1983, Welch 1981). Infants grow adequately with breastmilk (Michel 1994, Smith 1992, Stead 1987, Alpert 1983, Welch 1981).

Virtually all medications used in the treatment of CF are compatible with breastfeeding (Kroon 2018): H2 antagonists (famotidine, nizatidine, ranitidine), metoclopramide, domperidone, laxatives (polyethylene glycol, senna, bisacodyl), all antibiotics except for chloramphenicol, antifungals such as fluconazole, antiviral agents such as acyclovir and valacyclovir, antidiabetics (insulin, glibenclamide, tolbutamide), pamidronate, ursodeoxycholic acid, systemic and inhaled corticosteroids, inhaled bronchodilators, pancreatic enzymes, dornase alfa, vitamins, immunosuppressants (azathioprine, cyclosporine and tacrolimus) and ibuprofen. There is little data on the cystic fibrosis transmembrane conductance regulator (CFTR) protein enhancers, lumacaftor and ivacaftor, but limited data indicates that milk excretion is minimal and they can be administered during breastfeeding.

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Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Maternal Cystic Fybrosis is also known as


Maternal Cystic Fybrosis belongs to this group or family:


  1. Kroon MAGM, Akkerman-Nijland AM, Rottier BL, Koppelman GH, Akkerman OW, Touw DJ. Drugs during pregnancy and breast feeding in women diagnosed with Cystic Fibrosis - An update. J Cyst Fibros. 2018 Jan;17(1):17-25. Abstract
  2. McGuire E, Sappl PG. Breastfeeding with cystic fibrosis. Breastfeed Rev. 2016 Mar;24(1):37-40. No abstract available. Abstract
  3. Edenborough FP, Borgo G, Knoop C, Lannefors L, Mackenzie WE, Madge S, Morton AM, Oxley HC, Touw DJ, Benham M, Johannesson M; European Cystic Fibrosis Society.. Guidelines for the management of pregnancy in women with cystic fibrosis. J Cyst Fibros. 2008 Jan;7 Suppl 1:S2-32. Epub 2007 Nov 19. Abstract Full text (link to original source) Full text (in our servers)
  4. Festini F, Ciuti R, Taccetti G, Repetto T, Campana S, De Martino M. Breast-feeding in a woman with cystic fibrosis undergoing antibiotic intravenous treatment. J Matern Fetal Neonatal Med. 2006 Jun;19(6):375-6. Abstract
  5. Festini F. Ciuti R, Repetto T, Taccetti G, Neri A, Campana S, Mergni G, de Martino M. Safety of breast-feeding during an IV tobramycin course for infants of CF women. Pediatr Pulmonol Suppl. 2004;27:288-9. Poster-Abstract 291. 2004
  6. Michel SH, Mueller DH. Impact of lactation on women with cystic fibrosis and their infants: a review of five cases. J Am Diet Assoc. 1994 Feb;94(2):159-65. Abstract
  7. Kent NE, Farquharson DF. Cystic fibrosis in pregnancy. CMAJ. 1993 Sep 15;149(6):809-13. Review. Abstract Full text (link to original source) Full text (in our servers)
  8. Hamosh M, Bitman J. Human milk in disease: lipid composition. Lipids. 1992 Nov;27(11):848-57. Review. Abstract
  9. Smith PK, Tamlin N, Robertson E. Breast milk and cystic fibrosis. Med J Aust. 1992 Aug 17;157(4):283. No abstract available. Abstract
  10. Shiffman ML, Seale TW, Flux M, Rennert OR, Swender PT. Breast-milk composition in women with cystic fibrosis: report of two cases and a review of the literature. Am J Clin Nutr. 1989 Apr;49(4):612-7. Abstract
  11. Bitman J, Hamosh M, Wood DL, Freed LM, Hamosh P. Lipid composition of milk from mothers with cystic fibrosis. Pediatrics. 1987 Dec;80(6):927-32. Abstract
  12. Stead RJ, Brueton MJ, Hodson ME, Batten JC. Should mothers with cystic fibrosis breast feed? Arch Dis Child. 1987 Apr;62(4):433. No abstract available. Abstract Full text (link to original source) Full text (in our servers)
  13. Alpert SE, Cormier AD. Normal electrolyte and protein content in milk from mothers with cystic fibrosis: an explanation for the initial report of elevated milk sodium concentration. J Pediatr. 1983 Jan;102(1):77-80. No abstract available. Abstract
  14. Welch MJ, Phelps DL, Osher AB. Breast-feeding by a mother with cystic fibrosis. Pediatrics. 1981 May;67(5):664-6. Abstract

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