Last update: March 22, 2018

Fluconazole

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Excreted into breast milk in much lesser amount than that used for the treatment of Candida infection in the infant. Problems have not appeared in breastfed infants from treated mothers.

Widely used for the treatment of breast pain due or allegedly due to Candida infection. In those cases of breast candidiasis where topical treatment fails, oral Fluconazole may be used at a dose of 200 mg for the first day to be followed by 100 mg daily for two weeks.

The American Academy of Pediatrics rates it compatible with breastfeeding.

Alternatives

We do not have alternatives for Fluconazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Fluconazole in other languages or writings:

Group

Fluconazole belongs to this group or family:

Tradenames

Main tradenames from several countries containing Fluconazole in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 90 %
Molecular weight 306 daltons
Protein Binding 11 - 15 %
VD 0,7 - 0,8 l/Kg
Tmax 1 - 2 hours
T1/2 30 - 40 hours
M/P ratio 0,5 - 0,9 -
Theoretical Dose 0,4 - 0, 6 mg/Kg/d
Relative Dose 12 - 18 %
Relat.Ped.Dose 7 - 10 %

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Pereira CA, da Costa AC, Machado AK, Beltrame Júnior M, Zöllner MS, Junqueira JC, Jorge AO. Enzymatic activity, sensitivity to antifungal drugs and Baccharis dracunculifolia essential oil by Candida strains isolated from the oral cavities of breastfeeding infants and in their mothers' mouths and nipples. Mycopathologia. 2011 Abstract
  3. Hanna L, Cruz SA. Candida mastitis: a case report. Perm J. 2011 Abstract Full text (link to original source) Full text (in our servers)
  4. Moorhead AM, Amir LH, O'Brien PW, Wong S. A prospective study of fluconazole treatment for breast and nipple thrush. Breastfeed Rev. 2011 Abstract
  5. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Abstract Full text (link to original source) Full text (in our servers)
  6. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  7. Carmichael AR, Dixon JM. Is lactation mastitis and shooting breast pain experienced by women during lactation caused by Candida albicans? Breast. 2002 Abstract
  8. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  9. Brent NB. Thrush in the breastfeeding dyad: results of a survey on diagnosis and treatment. Clin Pediatr (Phila). 2001 Abstract
  10. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  11. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  12. Hoover K. Breast pain during lactation that resolved with fluconazole: two case studies. J Hum Lact. 1999 Abstract
  13. Bodley V, Powers D. Long-term treatment of a breastfeeding mother with fluconazole-resolved nipple pain caused by yeast: a case study. J Hum Lact. 1997 Abstract
  14. Debruyne D. Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses. Clin Pharmacokinet. 1997 Abstract
  15. Force RW. Fluconazole concentrations in breast milk. Pediatr Infect Dis J. 1995 Abstract
  16. Dhondt F, Ninane J, De Beule K, Dhondt A, Cauwenbergh G. Oral candidosis: treatment with absorbable and non-absorbable antifungal agents in children. Mycoses. 1992 Abstract

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