Last update: Aug. 31, 2020

Magnesium Carbonate

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Various magnesium salts, such as carbonate, hydroxide, oxide, peroxide, silicate and trisilicate are used as antacids and carbonate, citrate, oxide, peroxide and sulphate as osmotic laxatives.

Daily magnesium requirements for breastfeeding mothers are estimated at 310 to 360 mg (MedlinePlus 2017); some countries have established figures of up to 450 mg daily (Hall 2010).

Since the last update we have not found any published data on its excretion in breast milk.

Magnesium is a natural component of milk. The average natural concentration of magnesium in milk is 31 mg/L (15 to 64 mg/L) (Dórea 2000, Feeley 1983).

When ingested, magnesium does not concentrate in breastmilk. Its concentration in milk is very stable and depends little on diet (USD 2000) and other factors, including intravenous administration of magnesium sulphate to the mother: the levels of magnesium in milk of mothers treated with intravenous magnesium sulphate increased in clinically non-significant amounts in relation to mothers not in treatment (Cruikshank 1982, Dorea 2000).

Its low oral bioavailability (AEMPS 2017, Morris 1987) hinders transfer to plasma and, therefore, to breastmilk, as well as transfer to infant plasma via breastmilk.

If the intravenous administration of magnesium sulphate is considered compatible with breastfeeding, all the more reason that salts administered orally will also be compatible (Hagemann 1998).

Various medical associations and expert consensus consider the use of various magnesium salts to be safe during breastfeeding (Hale 2019, Briggs 2015, Dennis 2012, Schaefer 2007, Mahadevan 2006, Richter 2005, Nice 2000, Broussard 1998, Idama 1998).
The manufacturer considers the use of magnesium carbonate to be safe during breastfeeding (AEMPS-BAYER 2017).


See below the information of this related product:

Alternatives

We do not have alternatives for Magnesium Carbonate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Magnesium Carbonate in other languages or writings:

Groups

Magnesium Carbonate belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Magnesium Carbonate in its composition:

List of 25 tradenames
  • Acinat™. Contains other elements than Magnesium Carbonate in its composition
  • Acyline™. Contains other elements than Magnesium Carbonate in its composition
  • Andrews Antacid™. Contains other elements than Magnesium Carbonate in its composition
  • Antiacid™. Contains other elements than Magnesium Carbonate in its composition
  • Biolectra Magnesium 365™
  • Eupeptina™. Contains other elements than Magnesium Carbonate in its composition
  • Flor Antacid™. Contains other elements than Magnesium Carbonate in its composition
  • Gastricur™. Contains other elements than Magnesium Carbonate in its composition
  • Gelodrox™. Contains other elements than Magnesium Carbonate in its composition
  • Mag 2™
  • Mag-Carb™
  • Magmix II™
  • MagneBind™. Contains other elements than Magnesium Carbonate in its composition
  • Magnofit™
  • Marblen™. Contains other elements than Magnesium Carbonate in its composition
  • Mi-Acid Gelcaps™. Contains other elements than Magnesium Carbonate in its composition
  • Mylagen™. Contains other elements than Magnesium Carbonate in its composition
  • OsvaRen™
  • Osvaren™. Contains other elements than Magnesium Carbonate in its composition
  • Polvo Roge™
  • Rennie™. Contains other elements than Magnesium Carbonate in its composition
  • Sargemag™
  • Total Magnesiano™. Contains other elements than Magnesium Carbonate in its composition
  • Total Magnesiano E™. Contains other elements than Magnesium Carbonate in its composition
  • Total Magnesiano con Ginseng™. Contains other elements than Magnesium Carbonate in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 15 -20 %
Molecular weight 85 daltons
Protein Binding 30 %
VD 0,2 - 0,4 l/Kg

References

  1. MedlinePlus. Magnesium in diet. Medical Encyclopedia 2017 Full text (link to original source) Full text (in our servers)
  2. AEMPS-BAYER. Carbonato de Magnesio (Rennie). Ficha técnica. 2017 Full text (in our servers)
  3. MedlinePlus. Magnesio en la dieta. Enciclopedia médica. 2017 Full text (link to original source) Full text (in our servers)
  4. Dennis AT. Management of pre-eclampsia: issues for anaesthetists. Anaesthesia. 2012 Sep;67(9):1009-20. Abstract Full text (link to original source) Full text (in our servers)
  5. Hall Moran V, Lowe N, Crossland N, Berti C, Cetin I, Hermoso M, Koletzko B, Dykes F. Nutritional requirements during lactation. Towards European alignment of reference values: the EURRECA network. Matern Child Nutr. 2010 Oct;6 Suppl 2:39-54. Abstract Full text (link to original source) Full text (in our servers)
  6. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007
  7. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  8. Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005 Nov 1;22(9):749-57. Review. Abstract Full text (in our servers)
  9. Dórea JG. Magnesium in human milk. J Am Coll Nutr. 2000 Apr;19(2):210-9. Review. Abstract
  10. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  11. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998 Sep;14(3):259-62. Review. Abstract
  12. Broussard CN, Richter JE. Treating gastro-oesophageal reflux disease during pregnancy and lactation: what are the safest therapy options? Drug Saf. 1998 Oct;19(4):325-37. Review. Abstract
  13. Idama TO, Lindow SW. Magnesium sulphate: a review of clinical pharmacology applied to obstetrics. Br J Obstet Gynaecol. 1998 Mar;105(3):260-8. Review. No abstract available. Abstract
  14. Morris ME, LeRoy S, Sutton SC. Absorption of magnesium from orally administered magnesium sulfate in man. J Toxicol Clin Toxicol. 1987;25(5):371-82. Abstract
  15. Feeley RM, Eitenmiller RR, Jones JB Jr, Barnhart H. Calcium, phosphorus, and magnesium contents of human milk during early lactation. J Pediatr Gastroenterol Nutr. 1983 May;2(2):262-7. Abstract
  16. Cruikshank DP, Varner MW, Pitkin RM. Breast milk magnesium and calcium concentrations following magnesium sulfate treatment. Am J Obstet Gynecol. 1982 Jul 15;143(6):685-8. No abstract available. Abstract
  17. Hale TW. Hale's Medications & Mothers' Milk. [Internet]. Springer Publishing Company; 1991-. Available from: https://www.halesmeds.com None

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