Last update: June 30, 2019

Magnesium Sulfate

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

El sulfato de magnesio por vía intravenosas se utiliza en el tratamiento de cierta arritmias, en las convulsiones de la eclampsia y del recién nacido y lactante, por vía oral como laxante osmótico y en la profilaxis de la migraña (Pringsheim 2012) y, de modo tópico, en algunas inflamaciones cutáneas.

Las necesidades de magnesio en madres lactantes se estiman en 310 a 360 mg diarios (MedlinePlus 2017); algunos países establecen cifras de hasta 450 mg diarios (Hall 2010).

El magnesio es un componente natural de la leche. La concentración media natural de magnesio en leche es de 31 mg/L (15 a 64 mg/L) (Dórea 2000, Feeley 1983).

El magnesio ingerido no se concentra en la leche materna. Su concentración en la leche es muy estable y depende poco de la alimentación (Dórea 2000) y otros factores, incluida la administración intravenosa de sulfato de magnesio a la madre: los niveles de magnesio en leche de madres tratadas con sulfato de magnesio intravenoso fueron de 6,4 mg/L frente a 4,8 mg/L en las no tratadas (Cruikshank 1982, Dorea 2000), una diferencia clínicamente no significativa para el lactante, que además desapareció a las pocas horas.

Su baja biodisponibilidad oral dificulta el paso a plasma y, por tanto, a leche de la madre, así como el paso a plasma del lactante a partir de la leche materna ingerida (Morris 1987).

En mujeres tratadas con sulfato de magnesio antes o durante el parto, se ha observado retraso en la subida de la leche o lactogénesis II (Haldeman 1993) y menos frecuencia de lactancia (Meier 2005) así como hipotonía en los recién nacidos (Riaz 1998, Rasch 1982), lo que podría interferir en la estimulación mamaria adecuada, pero esto puede ser contrarrestado por una decisión materna firme y un apoyo eficaz a la madre (Cordero 2012).

Diversas sociedades médicas y consensos de expertos consideran seguro el uso de las diversas sales de magnesio durante la lactancia (Hale 2019, Briggs 2015, Dennis 2012, Schaefer 2007, Mahadevan 2006, Richter 2005, Nice 2000, Broussard 1998, Idama 1998).
Academia Americana de Pediatría: medicación usualmente compatible con la lactancia (AAP 2001).
Listado de medicamentos esenciales OMS: compatible con la lactancia (WHO 2002).

Si la administración intravenosa de sufato de magnesio es considerada compatible con la lactancia, con más razón las sales administradas por vía oral lo serán (Hagemann 1998).

Alternatives

We do not have alternatives for Magnesium Sulfate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Magnesium Sulfate is also known as


Magnesium Sulfate in other languages or writings:

Tradenames

Main tradenames from several countries containing Magnesium Sulfate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 4 - 15 %
Molecular weight 120 - 247 daltons
Protein Binding 25 - 40 %
Tmax 0,01 hours
T1/2 3 - 4 hours
M/P ratio 2 -
Theoretical Dose 4,6 mg/Kg/d
Relative Dose 0,2 %

References

  1. Hale TW. Hale's Medications & Mothers' Milk. Springer Publishing Company. 2019
  2. MedlinePlus. Magnesium in diet. Medical Encyclopedia 2017 Full text (link to original source) Full text (in our servers)
  3. MedlinePlus. Magnesio en la dieta. Enciclopedia médica. 2017 Full text (link to original source) Full text (in our servers)
  4. Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, Christie SN, Gladstone J, Becker WJ; Canadian Headache Society Prophylactic Guidelines Development Group. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci. 2012 Abstract Full text (in our servers)
  5. Dennis AT. Management of pre-eclampsia: issues for anaesthetists. Anaesthesia. 2012 Sep;67(9):1009-20. Abstract Full text (link to original source) Full text (in our servers)
  6. Cordero L, Valentine CJ, Samuels P, Giannone PJ, Nankervis CA. Breastfeeding in women with severe preeclampsia. Breastfeed Med. 2012 Abstract
  7. Hall Moran V, Lowe N, Crossland N, Berti C, Cetin I, Hermoso M, Koletzko B, Dykes F. Nutritional requirements during lactation. Towards European alignment of reference values: the EURRECA network. Matern Child Nutr. 2010 Oct;6 Suppl 2:39-54. Abstract Full text (link to original source) Full text (in our servers)
  8. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007
  9. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  10. Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005 Nov 1;22(9):749-57. Review. Abstract Full text (in our servers)
  11. Meier B, Huch R, Zimmermann R, von Mandach U. Does continuing oral magnesium supplementation until delivery affect labor and puerperium outcome? Eur J Obstet Gynecol Reprod Biol. 2005 Dec 1;123(2):157-61. Abstract
  12. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  13. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  14. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  15. Dórea JG. Magnesium in human milk. J Am Coll Nutr. 2000 Apr;19(2):210-9. Review. Abstract
  16. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998 Sep;14(3):259-62. Review. Abstract
  17. Broussard CN, Richter JE. Treating gastro-oesophageal reflux disease during pregnancy and lactation: what are the safest therapy options? Drug Saf. 1998 Oct;19(4):325-37. Review. Abstract
  18. Riaz M, Porat R, Brodsky NL, Hurt H. The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study. J Perinatol. 1998 Abstract
  19. Idama TO, Lindow SW. Magnesium sulphate: a review of clinical pharmacology applied to obstetrics. Br J Obstet Gynaecol. 1998 Mar;105(3):260-8. Review. No abstract available. Abstract
  20. Haldeman W. Can magnesium sulfate therapy impact lactogenesis? J Hum Lact. 1993 Abstract
  21. Morris ME, LeRoy S, Sutton SC. Absorption of magnesium from orally administered magnesium sulfate in man. J Toxicol Clin Toxicol. 1987;25(5):371-82. Abstract
  22. Feeley RM, Eitenmiller RR, Jones JB Jr, Barnhart H. Calcium, phosphorus, and magnesium contents of human milk during early lactation. J Pediatr Gastroenterol Nutr. 1983 May;2(2):262-7. Abstract
  23. Cruikshank DP, Varner MW, Pitkin RM. Breast milk magnesium and calcium concentrations following magnesium sulfate treatment. Am J Obstet Gynecol. 1982 Jul 15;143(6):685-8. No abstract available. Abstract
  24. Rasch DK, Huber PA, Richardson CJ, L'Hommedieu CS, Nelson TE, Reddi R. Neurobehavioral effects of neonatal hypermagnesemia. J Pediatr. 1982 Feb;100(2):272-6. Abstract

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