Last update: May 22, 2019


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Vitamin B12 exists naturally in milk at a concentration of 1 nanogram / mL (Sauberan 2019; range: 0.3 to 3 ng / mL). Maternal supplementation with cyanocobalamin barely increases milk levels in well-nourished women (Sandberg 1981), but it does improve the levels in women of low socioeconomic status (Sneed 1981). The concentration in colostrum is up to 28 times higher than that of mature milk.
The daily requirements for Vitamin B12 are 2.4 micrograms (Sauberan 2019) and increase to 2.8 micrograms daily during breastfeeding. Foods rich in vitamin B12 are meat, offal, eggs, dairy products, salmon, sardines, clams and fortified cereals.

With a varied and balanced diet no vitamin supplements are needed, but B12 deficiency has been observed in the plasma and milk of women with strict vegetarian diets (vegans), malabsorptive diseases (eg, Crohn's disease, celiac disease), bariatric surgery, poor nutritional status, pernicious anemia, low socio-economic status and in cases of natural disasters or wars. There are numerous publications showing that infants of these mothers are at high risk of disease due to vitamin B12 deficiency, which can lead to anemia, stunting and psychomotor retardation.

"Flash pasteurization" applied to breast milk of mothers who are HIV+ does not decrease vitamin B12 concentration.

American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).

See below the information of this related product:


We do not have alternatives for Cobamin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Cobamin belongs to this group or family:


Main tradenames from several countries containing Cobamin in its composition:

  • Bago B1 B6 B12™. Contains other elements than Cobamin in its composition
  • Bedoyecta tri™. Contains other elements than Cobamin in its composition
  • Cromatonbic B12
  • Cyanokit
  • Elevit™. Contains other elements than Cobamin in its composition
  • Folyoben™. Contains other elements than Cobamin in its composition
  • Fortical (Mexico)™. Contains other elements than Cobamin in its composition
  • GyneFer™. Contains other elements than Cobamin in its composition
  • Hidroxil B12 B6 B1™. Contains other elements than Cobamin in its composition
  • Inzitan™. Contains other elements than Cobamin in its composition
  • Isopto B 12
  • Megamilbedoce
  • Multibionta Complex™. Contains other elements than Cobamin in its composition
  • Nervobion™. Contains other elements than Cobamin in its composition
  • Neurobion™. Contains other elements than Cobamin in its composition
  • Neuroflax (Mexico)™. Contains other elements than Cobamin in its composition
  • Optovite B12
  • Polper Vascular™. Contains other elements than Cobamin in its composition
  • Suplefol™. Contains other elements than Cobamin in its composition
  • Supradyn Forte™. Contains other elements than Cobamin in its composition
  • Supradyn Prenatal™. Contains other elements than Cobamin in its composition
  • Supradyn Pronatal™. Contains other elements than Cobamin in its composition
  • Trofalgon™. Contains other elements than Cobamin in its composition
  • Yodocefol™. Contains other elements than Cobamin in its composition
  • Yoduk Complex™. Contains other elements than Cobamin in its composition
  • Yofolvit™. Contains other elements than Cobamin in its composition


Variable Value Unit
Molecular weight 1344 - 2791 daltons
Tmax 2 hours
M/P ratio 1 -


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  3. Abe SK, Balogun OO, Ota E, Takahashi K, Mori R. Supplementation with multiple micronutrients for breastfeeding women for improving outcomes for the mother and baby. Cochrane Database Syst Rev. 2016 Abstract
  4. Ohyama W, Yamaoka M, Yokoi K, Iwahashi M, Inage Y, Arihiro S, Koganei K, Sugita A, Ida H, Akiyama M. [Maternal Crohn's disease-related vitamin B12 deficient megaloblastic anemia in an infant]. Rinsho Ketsueki. 2016 Abstract
  5. Bae S, West AA, Yan J, Jiang X, Perry CA, Malysheva O, Stabler SP, Allen RH, Caudill MA. Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes. J Nutr. 2015 Abstract
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  12. Duggan C, Srinivasan K, Thomas T, Samuel T, Rajendran R, Muthayya S, Finkelstein JL, Lukose A, Fawzi W, Allen LH, Bosch RJ, Kurpad AV. Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status. J Nutr. 2014 Abstract
  13. Neumann CG, Oace SM, Chaparro MP, Herman D, Drorbaugh N, Bwibo NO. Low vitamin B12 intake during pregnancy and lactation and low breastmilk vitamin 12 content in rural Kenyan women consuming predominantly maize diets. Food Nutr Bull. 2013 Abstract
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) from Mexico

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